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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser499 FMRP (Fragile X Mental Retardation Protein) Antibody品牌 |
Leading Biology | 貨號 |
APR12820G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser499 FMRP (Fragile X Mental Retardation Protein) antibody.
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分子量 |
71 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein that plays an essential role in cognitive brain function. Mutations in the FMR1 gene, which codes for FMRP, can result in fragile X syndrome, autism, as well as other cognitive deficits (Brown et al.,1998, Goodlin-Jones et al., 2004). Phosphorylation of the highly conserved Ser499 has been shown to trigger hierarchical phosphorylation of nearby serines and may play a role in suppressing target mRNA translation (Ceman et al., 2003, Narayanan et al. 2008).
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形式 |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~ 1:1000
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別名 |
Fragile X mental retardation protein 1 homolog, FMRP, Protein FMR-1, Fmr1
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圖像 |
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說明書 |
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數(shù)量 |
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