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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser549 Synapsin I Antibody

Phospho-Ser549 Synapsin I Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR12821G 100 μl / ￥5450

Phospho-Ser549 Synapsin I Antibody

品牌

 Leading Biology

貨號(hào)

 APR12821G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser549 Synapsin I antibody.

分子量
78 KDa

宿主
Rabbit

種屬反應(yīng)性
Rat

靶點(diǎn)
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser549 conjugated to KLH.

基因ID

UniProt ID

總結(jié)
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayaket al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability ofsynaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated byphosphorylation (Jovanovic et al.,2001; Kao et al., 2002). Ser549along with Ser62and Ser67are the sites ofsynapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequentdephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.

形式
Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephospho-peptide affinity columns.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC

稀釋方法
WB~~ 1:1000 IHC~~ 1:500

別名
Synapsin-1, Synapsin I, SYN1

圖像

Western blot of rat cortex lysate showing specific immunolabeling of the ~78k synapsin I phosphorylated at Ser549 (Control). Phosphospecificity is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min)before being exposed to the phospho Ser549 synapsin I antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase.

Immunostaining of cultured mouse caudate neurons showing synapsin I when phosphorylated at Ser549. Cells and photo courtesy of QBMCellScience.

說(shuō)明書(shū)

數(shù)量

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