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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser9 Synapsin I Antibody

Phospho-Ser9 Synapsin I Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR12838G 100 μl / ￥5450

Phospho-Ser9 Synapsin I Antibody

品牌

 Leading Biology

貨號(hào)

 APR12838G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser9 Synapsin I antibody.

分子量
78 KDa

宿主
Rabbit

種屬反應(yīng)性
Rat

靶點(diǎn)
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser9 conjugated to KLH.

基因ID

UniProt ID

總結(jié)
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al.,1996). This effect is due in large part to the abilityof the synapsins to regulate the availability of synapticvesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator ofsynapse formation (Moore and Bernstein, 1989; Stone etal., 1994). Thus, synapsin I immunocytochemistryprovides a valuable tool for the study of synaptogenesis.The role of synapsin in synaptic plasticity and insynaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Serine 9 is the siteon synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I(Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function and neuriteoutgrowth (Kao et al., 2002).

形式
Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephosphopeptide affinity columns.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC

稀釋方法
WB~~ 1:1000 IHC~~ 1:500

別名
Synapsin-1, Synapsin I, SYN1

圖像

Western blot of rat cortex lysate showing specific immunolabeling of ~78k synapsin I phosphorylated at Ser9 (Control). Phosphospecificity is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser9 synapsin I antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase.

Cultured mouse caudate neurons showing synapsin I when phosphorylated at Ser9.

說(shuō)明書(shū)

數(shù)量

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