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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR12838G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser9 Synapsin I antibody.
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分子量 |
78 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點(diǎn) |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser9 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al.,1996). This effect is due in large part to the abilityof the synapsins to regulate the availability of synapticvesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator ofsynapse formation (Moore and Bernstein, 1989; Stone etal., 1994). Thus, synapsin I immunocytochemistryprovides a valuable tool for the study of synaptogenesis.The role of synapsin in synaptic plasticity and insynaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Serine 9 is the siteon synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I(Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function and neuriteoutgrowth (Kao et al., 2002).
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形式 |
Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephosphopeptide affinity columns.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC
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稀釋方法 |
WB~~ 1:1000
IHC~~ 1:500
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別名 |
Synapsin-1, Synapsin I, SYN1
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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