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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser41 Gap-43 Antibody

Phospho-Ser41 Gap-43 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR12818G 100 μl / ￥5450

Phospho-Ser41 Gap-43 Antibody

品牌

 Leading Biology

貨號(hào)

 APR12818G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser41 Gap-43 antibody.

分子量
50 KDa

宿主
Rabbit

種屬反應(yīng)性
Rat

靶點(diǎn)
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 conjugated to KLH.

基因ID

UniProt ID

總結(jié)
Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin (He et al., 1997) and may also affect eurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).

形式
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB

稀釋方法
WB~~ 1:1000

別名
Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Protein F1, Gap43

圖像

Western blot of rat cortex lysate showing specific immunolabeling of the ~50k Gap-43 protein phosphorylated at Ser41 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the GAP-43 Ser41 antibody. The immunolabeling of GAP-43 is completely eliminated by treatment with λ-Ptase.

說(shuō)明書(shū)

數(shù)量

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