品牌 |
Leading Biology | 貨號 |
APR12284G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GRK2 antibody.
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分子量 |
79574 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}
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宿主 |
Rabbit
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種屬反應性 |
Human
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靶點 |
Human GRK2
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亞型 |
IgG
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通用名 |
BARK, BARK1, GRK2
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基因ID |
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UniProt ID |
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功能 |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
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總結 |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, E
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稀釋方法 |
IHC-P (10 μg/ml),
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別名 |
ADRBK1, BARK1, Beta-ARK-1, BETA-ARK1, BARK, Betaark1, GRK2
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圖像 |
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) |
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說明書 |
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數量 |
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