全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR15723G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DERL2 / Derlin-2 antibody.
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分子量 |
27567 Da
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細胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Multi- pass membrane protein
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse
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靶點 |
DERL2 / Derlin-2
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亞型 |
IgG
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通用名 |
DER2, FLANA
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基因ID |
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UniProt ID |
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功能 |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
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總結 |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P
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稀釋方法 |
IHC-P (5 μg/ml), WB (1:1000),
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別名 |
DERL2, Carcinoma related, CGI-101, DER2, Derlin 2, Derlin-2, F-LANa, F-LAN-1, FLANa, Der1-like protein 2, DERtrin-2
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圖像 |
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說明書 |
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數(shù)量 |
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