品牌 |
Leading Biology | 貨號 |
AMM08221G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TLK1 antibody (aa730-779).
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分子量 |
86700 Da
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細胞定位 |
Antigen Cellular Localization:
Nucleus
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse
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靶點 |
TLK1 Antibody detects endogenous levels of total TLK1 protein.
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亞型 |
IgG
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通用名 |
KIAA0137
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基因ID |
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UniProt ID |
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功能 |
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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總結 |
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
IHC-P, IF, E
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稀釋方法 |
ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 μg/ml),
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別名 |
TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK
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圖像 |
Anti-TLK1 antibody IHC staining of human placenta. Immunofluorescence of COS7 cells, using TLK1 Antibody. |
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說明書 |
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數量 |
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