ULK3 Antibody (Internal)

AMM08430G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM08430G		50 μg / ￥4950

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ULK3 Antibody (Internal)

品牌	Leading Biology	貨號	AMM08430G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ULK3 antibody (Internal).
分子量	53kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	ULK3 antibody is human specific. Multiple isoforms of ULK3 are known to exist.
基因ID	25989
UniProt ID	Q6PHR2
功能	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
總結(jié)	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
稀釋方法	IF (20 μg/ml), IHC-P (10 μg/ml), WB (0.5-1 μg/ml)
別名	Serine/threonine-protein kinase ULK3, 2.7.11.1, Unc-51-like kinase 3, ULK3
圖像	Immunofluorescence of ULK3 in human brain tissue with ULK3 antibody at 20 g/mL. Anti-ULK3 antibody IHC staining of human liver. Western blot analysis of ULK3 in human brain tissue lysate with ULK3 antibody at (A) 0.5 and (B)...
說明書	Product Datasheet Protocol
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