TRIM33 / TIF1-Gamma Antibody (Internal)

APR17882G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17882G		50 μg / ￥4950

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TRIM33 / TIF1-Gamma Antibody (Internal)

品牌	Leading Biology	貨號(hào)	APR17882G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIM33 / TIF1-Gamma antibody (Internal).
分子量	123kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.
通用名	KIAA1113, RFG7, TIF1G
基因ID	51592
UniProt ID	Q9UPN9
功能	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
總結(jié)	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
稀釋方法	IF (20 μg/ml), IHC-P (10 μg/ml), WB (1-2 μg/ml)
別名	E3 ubiquitin-protein ligase TRIM33, 6.3.2.-, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113, RFG7, TIF1G
圖像	Western blot analysis of TRIM33 in human liver tissue lysate with TRIM33 antibody at (A) 1 and... Immunofluorescence of TRIM33 in human liver tissue with TRIM33 antibody at 20 ug/ml. Anti-TRIM33 / TIF1-Gamma antibody IHC staining of human prostate.
說(shuō)明書(shū)	Product Datasheet Protocol
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