全部產品分類
品牌 |
Leading Biology | 貨號 |
APR12414G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IFT57 / HIPPI antibody (Internal).
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分子量 |
49kDa
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia.
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宿主 |
Goat
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種屬反應性 |
Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse
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靶點 |
Human IFT57 / HIPPI.
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通用名 |
DERP8, ESRRBL1, HIPPI
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基因ID |
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UniProt ID |
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功能 |
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
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總結 |
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, E
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稀釋方法 |
ELISA (1:8000), IHC-P (5 μg/ml), WB (1-3 μg/ml)
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別名 |
Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI
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圖像 |
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說明書 |
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數(shù)量 |
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