VPS39 Antibody (C-Terminus)

AMM08488G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM08488G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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VPS39 Antibody (C-Terminus)

品牌	Leading Biology	貨號(hào)	AMM08488G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality VPS39 antibody (C-Terminus).
分子量	102kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	Human VPS39. At least four isoforms of VPS39 are known to exist; this antibody will detect all four. VPS39 antibody is predicted not to cross-react with TRAP1.
通用名	KIAA0770, TLP, VAM6
基因ID	23339
UniProt ID	Q96JC1
功能	May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.
總結(jié)	May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF
稀釋方法	IHC-P (5 μg/ml), WB (0.5-1 μg/ml),
別名	Vam6/Vps39-like protein, TRAP1-like protein, hVam6p, VPS39, KIAA0770, TLP, VAM6
圖像	Immunofluorescence of VPS39 in mouse liver tissue with VPS39 antibody at 20 ug/ml. Western blot analysis of VPS39 in rat liver tissue lysate with VPS39 antibody at 0.5 ug/ml in... Anti-VPS39 antibody IHC of human placenta.
說明書	Product Datasheet Protocol
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