TDP-43 / TARDBP Antibody (Internal)

APR11207G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR11207G		50 μg / ￥4950

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TDP-43 / TARDBP Antibody (Internal)

品牌	Leading Biology	貨號(hào)	APR11207G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TDP-43 / TARDBP antibody (Internal).
分子量	45kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	An 18 amino acid peptide from near the center of human TDP43. This antibody recognizes only the longer of the two isoforms.
通用名	TDP43
基因ID	23435
UniProt ID	Q13148
功能	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
總結(jié)	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, ICC
稀釋方法	IHC-P (5 μg/ml), WB (1 μg/ml),
別名	TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
圖像	Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 ug/ml. Immunofluorescence of TDP43 in HeLa cells with TDP43 antibody at 20 ug/ml. Western blot of TDP43 in L1210 cell lysate with TDP43 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
說明書	Product Datasheet Protocol
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