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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > JUP/CTNNG/Junction Plakoglobin Antibody (C-Terminus)品牌 |
Leading Biology | 貨號 |
APR16962G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality JUP/CTNNG/Junction Plakoglobin antibody (C-Terminus).
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分子量 |
82kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
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宿主 |
Goat
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種屬反應(yīng)性 |
Human, Mouse, Rabbit, Hamster, Monkey, Dog
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靶點 |
Human JUP / Gamma Catenin. This antibody is expected to recognise both reported isoforms, as represented by NP_002221.1 and NP_068831.1.
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通用名 |
CTNNG, DP3
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基因ID |
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UniProt ID |
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功能 |
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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總結(jié) |
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
ELISA (1:32000), IHC-P (5 μg/ml), WB (0.2-1 μg/ml)
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別名 |
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
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圖像 |
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說明書 |
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數(shù)量 |
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