Tuberin / TSC2 Antibody (phospho-Ser664)

APR10609G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR10609G		50 μl / ￥4950

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Tuberin / TSC2 Antibody (phospho-Ser664)

品牌	Leading Biology	貨號(hào)	APR10609G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Tuberin / TSC2 antibody (phospho-Ser664).
分子量	201kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	Modified peptide
通用名	TSC4
基因ID	7249
UniProt ID	P49815
功能	In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
總結(jié)	In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, IF, ICC
稀釋方法	IHC-P (1:50)
別名	Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
圖像	Untreated Hela cells (Panel A), or overnight nocodazole treated Hela cells (Panel B) stained...
說(shuō)明書	Product Datasheet Protocol
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