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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > PINK1 Antibody (aa484-504)

PINK1 Antibody (aa484-504)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMR09286G 1 ea / ￥4950

PINK1 Antibody (aa484-504)

品牌

 Leading Biology

貨號(hào)

 AMR09286G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PINK1 antibody (aa484-504).

分子量
63kDa

細(xì)胞定位
Antigen Cellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol

宿主
Rabbit

種屬反應(yīng)性
Human, Monkey

靶點(diǎn)
human PINK1 amino acids 484-504 (LVRALLQREASKRPSARVAAN)

基因ID

UniProt ID

功能
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).

總結(jié)
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P

稀釋方法
IHC-P (20 μg/ml)

別名
Serine/threonine-protein kinase PINK1, mitochondrial, 2.7.11.1, BRPK, PTEN-induced putative kinase protein 1, PINK1

圖像

Anti-PINK1 antibody IHC of human testis.

說(shuō)明書(shū)

數(shù)量

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