CIDEA / CIDE-A Antibody (aa200-217)

APG02598G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG02598G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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CIDEA / CIDE-A Antibody (aa200-217)

品牌	Leading Biology	貨號	APG02598G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CIDEA / CIDE-A antibody (aa200-217).
分子量	25kDa
細(xì)胞定位	Antigen Cellular Localization: Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062) {ECO:0000250, ECO:0000269\|PubMed:18509062}
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	peptide corresponding to amino acids 200 to 217 of human CIDE-A
基因ID	1149
UniProt ID	O60543
功能	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
總結(jié)	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF
稀釋方法	IHC-P (10 μg/ml), WB (1:1000-1:2000),
別名	Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA
圖像	Immunofluorescence of CIDE-A in Human Brain cells with CIDE-A antibody at 20 ug/ml. Western blot of CIDE-A in human brain tissue lysate in the absence (A) or presence (B) of... Anti-CIDE A antibody IHC of human testis.
說明書	Product Datasheet Protocol
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