DENN / MADD Antibody (C-Terminus)

APR07546G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR07546G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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DENN / MADD Antibody (C-Terminus)

品牌	Leading Biology	貨號	APR07546G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DENN / MADD antibody (C-Terminus).
分子量	183kDa
細(xì)胞定位	Antigen Cellular Localization: Membrane. Cytoplasm
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	peptide corresponding to amino acids near the carboxy terminus of human MADD
基因ID	8567
UniProt ID	Q8WXG6
功能	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
總結(jié)	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, ICC
稀釋方法	IHC-P (2.5 μg/ml), WB (1:250-1:500),
別名	MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor, MADD {ECO:0000312\|EMBL:AAB57735.1, ECO:0000312\|HGNC:HGNC:6766}
圖像	Immunocytochemistry of MADD in human spleen tissue with MADD antibody at 10 ug/ml. Immunofluorescence of MADD in HeLa cells with MADD antibody at 20 ug/ml.
說明書	Product Datasheet Protocol
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