CBLN1 / Cerebellin 1 Antibody

APR11566G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR11566G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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CBLN1 / Cerebellin 1 Antibody

品牌	Leading Biology	貨號(hào)	APR11566G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CBLN1 / Cerebellin 1 antibody.
分子量	21kDa
細(xì)胞定位	Antigen Cellular Localization: Secreted. Cell junction, synapse, postsynaptic cell membrane
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	15 amino acid peptide from the middle of human precerebellin
基因ID	869
UniProt ID	P23435
功能	Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
總結(jié)	Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P
稀釋方法	IHC-P (10 μg/ml), WB (2-4 μg/ml),
別名	Cerebellin-1, Precerebellin, Cerebellin, CER, [des-Ser1]-cerebellin, CBLN1
圖像	Western blot of precerebellin in mouse cerebellum lysate with APR11566G at (A) 2 and (B) 4 ug/ml. Anti-CBLN1 / Precerebellin antibody IHC of mouse small intestine. Anti-CBLN1 / Precerebellin antibody IHC of mouse kidney.
說明書	Product Datasheet Protocol
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