4E-BP1 Antibody (T45)

APG01381G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG01381G		0.1 mg / ￥4950

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4E-BP1 Antibody (T45)

品牌	Leading Biology	貨號(hào)	APG01381G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality 4E-BP1 antibody (T45).
分子量	12580 Da
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
亞型	Rabbit IgG
基因ID	1978
UniProt ID	Q13541
功能	Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
總結(jié)	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
形式	affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:500~1:1000 IHC~~1:50~1:100
別名	Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
圖像	Western blot analysis of extracts from MDA-MB-435 cells untreated or treated with EGF (200ng/ml, 5min), using 4E-BP1 Antibody (T45) ( APG01381G, Lane1 and 2) and Phospho-4E-BP1-T45 Antibody ( Lane 3 and 4). Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 4E-BP1 Antibody (T45)( APG01381G).
說明書	Product Datasheet Protocol
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