HDAC1 Antibody(C-term)

AMM08777G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM08777G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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HDAC1 Antibody(C-term)

品牌	Leading Biology	貨號(hào)	AMM08777G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HDAC1 antibody(C-term).
分子量	H=55;M=55;Rat=55 KDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus.
宿主	Rabbit
種屬反應(yīng)性	Human, Rat
免疫原	421-450 aa
靶點(diǎn)	This HDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 421-450 amino acids from the C-terminal region of human HDAC1.
通用名	RPD3L1
基因ID	3065
UniProt ID	Q13547
功能	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
總結(jié)	Histone acetylation and deacetylation, catalyzed bymultisubunit complexes, play a key role in the regulation ofeukaryotic gene expression. The protein encoded by this genebelongs to the histone deacetylase/acuc/apha family and is acomponent of the histone deacetylase complex. It also interactswith retinoblastoma tumor-suppressor protein and this complex is akey element in the control of cell proliferation anddifferentiation. Together with metastasis-associated protein-2, itdeacetylates p53 and modulates its effect on cell growth andapoptosis.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:1000
別名	HDAC1; RPD3L1; Histone deacetylase 1
圖像	Western blot analysis of lysates from Hela,K562 cell line,rat spleen tissue lysate (from left to right), using HDAC1 Antibody (C-term)(Cat. AMM08777G). AMM08777G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
說(shuō)明書(shū)	Product Datasheet Protocol
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