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TRIM11 (aa249-263) Antibody (internal region)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR13802G 0.1 mg / ￥4950

TRIM11 (aa249-263) Antibody (internal region)

品牌

 Leading Biology

貨號(hào)

 APR13802G

產(chǎn)品分類(lèi)

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIM11 (aa249-263) antibody (internal region).

分子量
52774 Da

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm. Nucleus.

宿主
Goat

種屬反應(yīng)性
Human

亞型
IgG

通用名
RNF92

基因ID

UniProt ID

功能
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

形式
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, E

別名
E3 ubiquitin-protein ligase TRIM11, 6.3.2.-, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11, TRIM11, RNF92

圖像

APR13802G (0.3 μg/ml) staining of Human Spleen lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

說(shuō)明書(shū)

數(shù)量

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