全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM05089G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
|
產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Goat Anti-PLA2R1 antibody.
|
||
分子量 |
168600 Da
|
||
細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Isoform 2: Secreted.
|
||
宿主 |
Goat
|
||
種屬反應(yīng)性 |
Human
|
||
亞型 |
IgG
|
||
通用名 |
CLEC13C
|
||
基因ID |
|||
UniProt ID |
|||
功能 |
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.
|
||
總結(jié) |
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.
|
||
形式 |
0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
|
||
儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
應(yīng)用 |
WB, E
|
||
別名 |
Secretory phospholipase A2 receptor, PLA2-R, PLA2R, 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, M-type receptor, Soluble secretory phospholipase A2 receptor, Soluble PLA2-R, Soluble PLA2R, PLA2R1, CLEC13C
|
||
圖像 |
|
||
說(shuō)明書 |
|||
數(shù)量 |
|
||
| 選擇 | 品牌 | 貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說(shuō)明書 | 數(shù)量 | 目錄價(jià) | |
| 1 | Leading Biology | APR05963G | EGFR Antibody (Y1092) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 訂購(gòu) 詢價(jià) | ||
| 2 | Leading Biology | APR03116G | BRCA1 Antibody (aa1847-1863) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 訂購(gòu) 詢價(jià) | ||
| 3 | Leading Biology | AMM05633G | Bombesin Receptor 2 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 訂購(gòu) 詢價(jià) | ||
| 4 | Leading Biology | APR10986G | AP3B1 Antibody (aa2-14) | 50 μg | Polyclonal Antibodies |
|
￥4950.00 | 訂購(gòu) 詢價(jià) | ||
| 5 | Leading Biology | APR11512G | Bestrophin-1 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 訂購(gòu) 詢價(jià) | ||
| 6 | Leading Biology | APG01407G | A3 Adenosine Receptor Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 訂購(gòu) 詢價(jià) |
.jpg)
微信掃描二維碼，隨時(shí)隨地與小諾親密接觸，精彩活動(dòng)，勁爆優(yōu)惠，觸手可得！
銷售-華東區(qū)