Goat Anti-SIRT4 Antibody

AMM05121G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM05121G		0.1 mg / ￥4950

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Goat Anti-SIRT4 Antibody

品牌	Leading Biology	貨號	AMM05121G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-SIRT4 antibody.
分子量	35188 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion matrix {ECO:0000255\|HAMAP- Rule:MF_03161, ECO:0000269\|PubMed:16079181, ECO:0000269\|PubMed:16959573, ECO:0000269\|PubMed:17715127}
宿主	Goat
種屬反應(yīng)性	Human, Rat
亞型	IgG
通用名	SIR2L4
基因ID	23409
UniProt ID	Q9Y6E7
功能	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
總結(jié)	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
形式	0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, E
別名	NAD-dependent protein deacetylase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 3.5.1.- {ECO:0000255\|HAMAP-Rule:MF_03161}, NAD-dependent ADP-ribosyltransferase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 2.4.2.- {ECO:0000255\|HAMAP-Rule:MF_03161}, Regulatory protein SIR2 homolog 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2-like protein 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIRT4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2L4
圖像	AMM05121G (0.05ug/ml) staining of Human Kidney (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.chemiluminescence. HEK293 overexpressing SIRT4 (RC212226) and probed with AF1361a (mock transfection in first lane), tested by Origene. AMM05121G (2 μg/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
說明書	Product Datasheet Protocol
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