全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APG03347G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Goat Anti-Claudin 14 / CLDN14 antibody.
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分子量 |
25699 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
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宿主 |
Goat
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種屬反應(yīng)性 |
Human, Mouse
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亞型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.
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總結(jié) |
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.
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形式 |
0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, E
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別名 |
Claudin-14, CLDN14
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圖像 |
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說明書 |
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數(shù)量 |
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