Goat Anti-BARK1 / GRK2 Antibody

AMM05927G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM05927G		0.1 mg / ￥4950

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Goat Anti-BARK1 / GRK2 Antibody

品牌	Leading Biology	貨號(hào)	AMM05927G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-BARK1 / GRK2 antibody.
分子量	79574 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm {ECO:0000250\|UniProtKB:P21146}. Cell membrane {ECO:0000250\|UniProtKB:P21146}
宿主	Goat
種屬反應(yīng)性	Human
亞型	IgG
通用名	BARK, BARK1, GRK2
基因ID	156
UniProt ID	P25098
功能	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
總結(jié)	The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
形式	0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
別名	Beta-adrenergic receptor kinase 1, Beta-ARK-1, 2.7.11.15, G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2
圖像	AMM05927G (0.3 μg/ml) staining of Daudi cell lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
說(shuō)明書(shū)	Product Datasheet Protocol
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