全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR12953G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Procathepsin K antibody.
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分子量 |
37104 Da
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細胞定位 |
Antigen Cellular Localization:
Lysosome.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點 |
Procathepsin K
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亞型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Important for the overall degradation of proteins in lysosomes.
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總結(jié) |
Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of Procathepsin K to mature Cathepsin K is autocatalytic.
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形式 |
100 μg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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別名 |
CTSK, CTSO, CTSO3
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圖像 |
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說明書 |
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數(shù)量 |
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