全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM07596G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RGS3 antibody.
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分子量 |
132336 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
RGS3
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亞型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
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總結(jié) |
RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed in many tissues and cells. The protein contains an RGS domain near the carboxy terminus that serves as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Giα and Gαq. A truncated RGS3 (RGS3T), with its N-terminal 313 residues removed, has been shown to negatively regulate acenylyl cyclase and PLC. RGS3T may be localized in the nucleus and RGS3 is found in cytoplasm. Translocation to membrane is important for the RGS proteins to interact with heterotrimeric G proteins.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IP
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別名 |
RGS3, 602189, P49796, C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ-RGS3, RGP3
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圖像 |
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說明書 |
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數(shù)量 |
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