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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Glial Fibrillary Acidic Protein (GFAP) Antibody品牌 |
Leading Biology | 貨號(hào) |
APG03337G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Glial Fibrillary Acidic Protein (GFAP) antibody.
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分子量 |
50 KDa
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宿主 |
rabbit
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種屬反應(yīng)性 |
Rat
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靶點(diǎn) |
Recombinant and purified bovine GFAP.
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基因ID |
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UniProt ID |
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總結(jié) |
Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2).
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形式 |
Unpurified neat serum
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF
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稀釋方法 |
WB~~ 1:5000
IF~~ 1:1000
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別名 |
Glial fibrillary acidic protein, GFAP, GFAP
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圖像 |
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說明書 |
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數(shù)量 |
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