FTO Antibody (NT)

AMM04629G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM04629G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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FTO Antibody (NT)

品牌	Leading Biology	貨號(hào)	AMM04629G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FTO antibody (NT).
分子量	58282 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Nucleus speckle
宿主	Rabbit
靶點(diǎn)	FTO
亞型	Rabbit IgG
通用名	KIAA1752
基因ID	79068
UniProt ID	Q9C0B1
功能	Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
總結(jié)	FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC
別名	FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein.
圖像	Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of NCI-H460 cell line lysate. (35 Hg protein).
說明書	Product Datasheet Protocol
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