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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > AKR1A1 Antibody (CT)

AKR1A1 Antibody (CT)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APG01648G 100 μl / ¥4950

AKR1A1 Antibody (CT)

品牌

Leading Biology

貨號(hào)

APG01648G

產(chǎn)品分類(lèi)

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AKR1A1 antibody (CT).

分子量

36573 Da

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse, Rat, Pig, Bovine

靶點(diǎn)

AKR1A1

亞型

Rabbit IgG

通用名

ALDR1, ALR

基因ID

UniProt ID

功能

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

總結(jié)

AKR1A1 (aldo-keto reductase family 1 member A1), also known as ALR (aldehyde reductase), DD3 (dihydrodiol dehydrogenase 3) or ALDR1 (alcohol dehydrogenase), is a widely and abundantly expressed member of the aldo-keto reductase (AKR) family of proteins. Members of the AKR family are soluble NADPH-dependent oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1A1 exists as a monomer and catalyzes the reduction of xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols. In particular, AKR1A1 efficiently catalyzes medium-chain and aromatic aldehydes. AKR1A1 participates in the biosynthetic pathways of cholesterol and triglyceride and plays a role in the activation of polycyclic aromatic hydrocarbons (PAHs).

形式

Liquid. In PBS containing 0.02% sodium azide.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC

別名

AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1

說(shuō)明書(shū)

數(shù)量

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