ROR2 Antibody (NT)

AMM07640G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM07640G		100 μl / ￥4950

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ROR2 Antibody (NT)

品牌	Leading Biology	貨號	AMM07640G
產(chǎn)品分類	Polyclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ROR2 antibody (NT).
分子量	104757 Da
細胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein
宿主	Rabbit
種屬反應性	Human
靶點	ROR2
亞型	Rabbit IgG
通用名	NTRKR2
基因ID	4920
UniProt ID	Q01974
功能	Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.
總結	ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 may play differential roles during the development of the nervous system. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1 or the autosomal recessive skeletal disorder, Robinow syndrome.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC, FC
別名	ROR2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2
圖像	Western blot analysis of ROR2 (arrow) using ROR2 Antibody (N-term). 293 cell lysates (2 μg/lane) either nontransfected (Lane 1) or transiently transfected with the ROR2 gene (Lane 2) were loaded Formalin-fixed and paraffin-embedded human kidney carcinoma reacted with ROR2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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