全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR17744G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAK6 antibody.
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分子量 |
74867 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat, Pig, Horse
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靶點 |
PAK6
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亞型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).
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總結(jié) |
The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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別名 |
Serine/threonine-protein kinase PAK 6; p21-activated kinase 6; PAK-6
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說明書 |
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數(shù)量 |
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