GCGR Antibody (Center)

AMM04746G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM04746G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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GCGR Antibody (Center)

品牌	Leading Biology	貨號	AMM04746G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GCGR antibody (Center).
分子量	54009 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	179-210 aa
靶點(diǎn)	This GCGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FOXC1.
亞型	Rabbit Ig
基因ID	2642
UniProt ID	P47871
功能	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
總結(jié)	This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Glucagon receptor, GL-R, GCGR
圖像	Western blot analysis of lysates from MCF-7 cell line, mouse kidney, rat liver tissue (from left to right), using GCGR Antibody (Center)( AMM04746G). AMM04746G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
說明書	Product Datasheet Protocol
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