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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > FOLR2 Antibody (N-term)

FOLR2 Antibody (N-term)

貨號 貨期 規(guī)格 / 價格 詢價
AMM04583G 100 μl / ¥4950

FOLR2 Antibody (N-term)

品牌

Leading Biology

貨號

AMM04583G

產品分類

Polyclonal Antibodies

研究領域

產品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FOLR2 antibody (N-term).

分子量

29280 Da

細胞定位

Antigen Cellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Secreted

宿主

Rabbit

種屬反應性

Human, Mouse

免疫原

18-46 aa

靶點

This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human FOLR2.

亞型

Rabbit Ig

基因ID

UniProt ID

功能

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

總結

FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.

形式

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

WB, IHC-P, FC, E

稀釋方法

WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50

別名

Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2

圖像

Western blot analysis of lysate from human placenta tissue, using FOLR2 Antibody (N-term)( AMM04583G). AMM04583G was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

Western blot analysis of lysates from MDA-MB-453 cell line, human placenta tissue lysate (from left to right), using FOLR2 Antibody (N-term) ( AMM04583G). AMM04583G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

Western blot analysis of lysate from human placenta tissue lysate, using FOLR2 Antibody (N-term)( AMM04583G). AMM04583G was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.

說明書

數(shù)量

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