全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11618G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CNTN1 antibody (Center).
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分子量 |
113320 Da
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細胞定位 |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
635-662 aa
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靶點 |
This CNTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the Central region of human CNTN1.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
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總結(jié) |
CNTN1 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1
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圖像 |
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說明書 |
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數(shù)量 |
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