NEURL Antibody (Center)

AMM06621G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM06621G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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NEURL Antibody (Center)

品牌	Leading Biology	貨號(hào)	AMM06621G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NEURL antibody (Center).
分子量	61860 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Perikaryon. Cell projection, dendrite Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) Colocalized with JAG1 at the cell surface.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	158-186 aa
靶點(diǎn)	This NEURL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the Central region of human NEURL.
亞型	Rabbit Ig
通用名	NEURL, NEURL1A, RNF67
基因ID	9148
UniProt ID	O76050
功能	Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
總結(jié)	NEURL is involved in the determination of cell fate in the neurogenic region of the embryo and plays a role in the determination of cell fate in the central nervous system. NEURL may act as a tumor suppressor whose inactivation could be associated with malignant progression of astrocytic tumors.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100
別名	E3 ubiquitin-protein ligase NEURL1, 632-, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, NEURL1, NEURL, NEURL1A, RNF67
圖像	Anti-NEURL Antibody (Center) at 1:1000 dilution + Y79 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 62 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Western blot analysis of NEURL Antibody (Center) (Cat. AMM06621G) in Y79 cell line lysates (35ug/lane). NEURL (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human brain tissue reacted with NEURL Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說(shuō)明書	Product Datasheet Protocol
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