YWHAZ Antibody (D231)

APR14005G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR14005G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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YWHAZ Antibody (D231)

品牌	Leading Biology	貨號(hào)	APR14005G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality YWHAZ antibody (D231).
分子量	27745 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	216-245 aa
靶點(diǎn)	This YWHAZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from human YWHAZ.
亞型	Rabbit Ig
基因ID	7534
UniProt ID	P63104
功能	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
總結(jié)	YWHAZ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:50~100 WB~~1:1000
別名	14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ
圖像	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with 14-3-3 protein zeta/delta antibody (C-term) (Cat. APR14005G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of hYWHAZ-D231 (Cat. APR14005G) in mouse brain tissue and MCF-7 cell line lysates (35ug/lane). YWHAZ (arrow) was detected using the purified Pab.
說明書	Product Datasheet Protocol
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