ALDH4A1 Antibody (Center)

APG01766G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG01766G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ALDH4A1 Antibody (Center)

品牌	Leading Biology	貨號	APG01766G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ALDH4A1 antibody (Center).
分子量	61719 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion matrix.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	288-314 aa
靶點(diǎn)	This ALDH4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-314 amino acids from the Central region of human ALDH4A1.
亞型	Rabbit Ig
通用名	ALDH4, P5CDH
基因ID	8659
UniProt ID	P30038
功能	Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
總結(jié)	ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:50~100 WB~~1:1000
別名	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH
圖像	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH4A1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of anti-ALDH4A1 Antibody (Center) (Cat. APG01766G) in HepG2 cell line lysates (35ug/lane). ALDH4A1(arrow) was detected using the purified Pab. Western blot analysis of ALDH4A1 (arrow) using rabbit polyclonal ALDH4A1 Antibody (Center) (Cat. APG01766G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ALDH4A1 gene.
說明書	Product Datasheet Protocol
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