品牌 |
Leading Biology | 貨號 |
APG02658G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CLIC5 antibody.
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分子量 |
46503 Da
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細胞定位 |
Antigen Cellular Localization:
Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Single-pass membrane protein. Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
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宿主 |
Rabbit
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種屬反應性 |
Human
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靶點 |
This CLIC5 antibody is generated from rabbits immunized with human recombinant CLIC5 protein.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).
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總結 |
Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
Chloride intracellular channel protein 5, CLIC5
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圖像 |
Western blot analysis of anti-CLIC5 Antibody (Cat. APG02658G) in K562 cell line lysates (35ug/lane). CLIC5(arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with CLIC5 antibody (Cat. APG02658G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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說明書 |
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數量 |
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