KCNJ2 Antibody (C-term)

AMM06108G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM06108G		100 μl / ￥4950

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KCNJ2 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	AMM06108G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCNJ2 antibody (C-term).
分子量	48288 Da
細(xì)胞定位	Antigen Cellular Localization: Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	401-427 aa
靶點(diǎn)	This KCNJ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the C-terminal region of human KCNJ2.
亞型	Rabbit Ig
通用名	IRK1
基因ID	3759
UniProt ID	P63252
功能	Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
總結(jié)	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. This protein is an integral membrane protein and inward-rectifier type potassium channel. This protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is racterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, FC, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
別名	Inward rectifier potassium channel 2, Cardiac inward rectifier potassium channel, Inward rectifier K(+) channel Kir21, IRK-1, hIRK1, Potassium channel, inwardly rectifying subfamily J member 2, KCNJ2, IRK1
圖像	Anti-KCNJ2 Antibody (C-term) at 1:1000 dilution + human brain lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Western blot analysis of KCNJ2 Antibody (C-term) (Cat. AMM06108G) in mouse lung tissue lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with KCNJ2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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