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HSC70 Interacting Protein HIP (ST13) Antibody品牌 |
Leading Biology | 貨號(hào) |
APR16725G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HSC70 Interacting Protein HIP (ST13) antibody.
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分子量 |
41332 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
50-80 aa
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靶點(diǎn) |
This HSC70 Interacting Protein HIP (ST13) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-80 amino acids from human HSC70 Interacting Protein HIP (ST13).
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亞型 |
Rabbit Ig
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通用名 |
AAG2, FAM10A1, HIP, SNC6
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基因ID |
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UniProt ID |
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功能 |
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
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總結(jié) |
ST13 is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this protein is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, WB, E
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稀釋方法 |
IHC-P~~1:10~50
WB~~1:1000
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別名 |
Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6
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圖像 |
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ST13 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of anti-ST13 Antibody (N-term) (Cat. APR16725G) pre-incubated with and without blocking peptide (BP6247a) in A2058 cell line lysate. ST13(arrow) was detected using the purified Pab . |
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說(shuō)明書(shū) |
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數(shù)量 |
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