SIRT5 Antibody (C-term)

APR09965G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR09965G		100 μl / ￥4950

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SIRT5 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR09965G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIRT5 antibody (C-term).
分子量	33881 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus Isoform 2: Mitochondrion {ECO:0000255\|HAMAP- Rule:MF_03160, ECO:0000269\|PubMed:21143562}
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	263-292 aa
靶點(diǎn)	This SIRT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human SIRT5.
亞型	Rabbit Ig
通用名	SIR2L5
基因ID	23408
UniProt ID	Q9NXA8
功能	NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
總結(jié)	SIRT5 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:50~100 WB~~1:1000
別名	NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255\|HAMAP-Rule:MF_03160}, 351- {ECO:0000255\|HAMAP-Rule:MF_03160}, Regulatory protein SIR2 homolog 5 {ECO:0000255\|HAMAP-Rule:MF_03160}, SIR2-like protein 5 {ECO:0000255\|HAMAP-Rule:MF_03160}, SIRT5 {ECO:0000255\|HAMAP-Rule:MF_03160}, SIR2L5
圖像	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. Western blot analysis of anti-SIRT5 Pab (Cat. APR09965G) in Jurkat cell line lysate (35ug/lane). SIRT5(arrow) was detected using the purified Pab.
說明書	Product Datasheet Protocol
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