全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11492G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality BBS10 antibody (C-term).
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分子量 |
80838 Da
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細胞定位 |
Antigen Cellular Localization:
Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
515-544 aa
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靶點 |
This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.
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亞型 |
Rabbit Ig
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通用名 |
C12orf58
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基因ID |
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UniProt ID |
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功能 |
Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
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總結 |
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, FC, E
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稀釋方法 |
WB~~1:1000
FC~~1:10~50
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別名 |
Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
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圖像 |
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說明書 |
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數(shù)量 |
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