Phospho-BAD(Y110) Antibody

APR09147G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR09147G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
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Phospho-BAD(Y110) Antibody

品牌	Leading Biology	貨號(hào)	APR09147G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-BAD(Y110) antibody.
分子量	18392 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y110 of human BAD.
亞型	Rabbit Ig
通用名	BBC6, BCL2L8
基因ID	572
UniProt ID	Q92934
功能	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
總結(jié)	The protein encoded by this gene is a member of the BCL-2family. BCL-2 family members are known to be regulators ofprogrammed cell death. This protein positively regulates cellapoptosis by forming heterodimers with BCL-xL and BCL-2, andreversing their death repressor activity. Proapoptotic activity ofthis protein is regulated through its phosphorylation. Proteinkinases AKT and MAP kinase, as well as protein phosphatasecalcineurin were found to be involved in the regulation of thisprotein. Alternative splicing of this gene results in twotranscript variants which encode the same isoform. [provided byRefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	DB, E
稀釋方法	DB~~1:500
別名	Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, BBC6, BCL2L8
圖像	Dot blot analysis of Phospho-BAD-Y110 Antibody Phospho-specific Pab (Cat. APR09147G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
說(shuō)明書	Product Datasheet Protocol
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