全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM07150G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Nephrin(Y1193)) antibody.
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分子量 |
134742 Da
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
This Nephrin Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1193 of human Nephrin.
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亞型 |
Rabbit Ig
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通用名 |
NPHN
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基因ID |
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UniProt ID |
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功能 |
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
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總結(jié) |
This gene encodes a member of the immunoglobulin family ofcell adhesion molecules that functions in the glomerular filtrationbarrier in the kidney. The gene is primarily expressed in renaltissues, and the protein is a type-1 transmembrane protein found atthe slit diaphragm of glomerular podocytes. The slit diaphragm isthought to function as an ultrafilter to exclude albumin and otherplasma macromolecules in the formation of urine. Mutations in thisgene result in Finnish-type congenital nephrosis 1, characterizedby severe proteinuria and loss of the slit diaphragm and footprocesses.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
DB, E
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稀釋方法 |
DB~~1:500
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別名 |
Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN
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圖像 |
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說明書 |
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數(shù)量 |
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