品牌 |
Leading Biology | 貨號(hào) |
APR13253G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SEMA6A antibody (C-term).
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分子量 |
114395 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
998-1028 aa
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靶點(diǎn) |
This SEMA6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1028 amino acids from the C-terminal region of human SEMA6A.
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亞型 |
Rabbit Ig
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通用名 |
KIAA1368, SEMAQ
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基因ID |
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UniProt ID |
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功能 |
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).
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總結(jié) |
SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, SEMA6A, KIAA1368, SEMAQ
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圖像 |
Western blot analysis of SEMA6A Antibody (C-term) Pab (Cat. APR13253G) pre-incubated without(lane 1) and with(lane 2) blocking peptide in HL-60 cell line lysate. SEMA6A (arrow) was detected using the purified Pab. Western blot analysis of anti-SEMA6A Antibody (C-term)(Cat. APR13253G) pre-incubated with(right lane) and without(left lane) blocking peptide in mouse cerebellum tissue lysate. SEMA6A (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human brain tissue reacted with SEMA6A antibody (C-term) (Cat. APR13253G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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說明書 |
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數(shù)量 |
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