全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM08422G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ULK2 antibody (Center S323).
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分子量 |
112694 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre- autophagosomal membrane
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
300-327 aa
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靶點 |
This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human ULK2.
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亞型 |
Rabbit Ig
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通用名 |
KIAA0623
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
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總結(jié) |
This gene encodes a protein that is similar to aserine/threonine kinase in C. elegans which is involved in axonalelongation. The structure of this protein is similar to the C.elegans protein in that both proteins have an N-terminal kinasedomain, a central proline/serine rich (PS) domain, and a C-terminal(C) domain. The gene is located within the Smith-Magenis syndromeregion on chromosome 17. Alternatively spliced transcript variantsencoding the same protein have been identified. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IF, WB, E
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稀釋方法 |
IF~~1:10~50
WB~~1:1000
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別名 |
Serine/threonine-protein kinase ULK2, Unc-51-like kinase 2, ULK2, KIAA0623
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圖像 |
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說明書 |
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數(shù)量 |
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