全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11366G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AKAP5 antibody (Center).
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分子量 |
47088 Da
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細胞定位 |
Antigen Cellular Localization:
Membrane; Lipid-anchor. Note=Associates with lipid rafts
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
115-143 aa
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靶點 |
This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
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亞型 |
Rabbit Ig
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通用名 |
AKAP79
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基因ID |
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UniProt ID |
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功能 |
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
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總結(jié) |
The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinbinds to the RII-beta regulatory subunit of PKA, and also toprotein kinase C and the phosphatase calcineurin. It ispredominantly expressed in cerebral cortex and may anchor the PKAprotein at postsynaptic densities (PSD) and be involved in theregulation of postsynaptic events. It is also expressed in Tlymphocytes and may function to inhibit interleukin-2 transcriptionby disrupting calcineurin-dependent dephosphorylation of NFAT.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
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圖像 |
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說明書 |
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數(shù)量 |
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