PIWIL2 Antibody (N-term)

AMM07206G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM07206G		100 μl / ￥4950

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PIWIL2 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	AMM07206G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PIWIL2 antibody (N-term).
分子量	109849 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity)
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	90-119 aa
靶點(diǎn)	This PIWIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human PIWIL2.
亞型	Rabbit Ig
通用名	HILI
基因ID	55124
UniProt ID	Q8TC59
功能	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).
總結(jié)	PIWIL2 belongs to the Argonaute family of proteins, whichfunction in development and maintenance of germline stem cells(Sasaki et al., 2003 [PubMed 12906857]).
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Piwi-like protein 2, Cancer/testis antigen 80, CT80, PIWIL2, HILI
圖像	Western blot analysis of lysate from mouse testis tissue lysate, using PIWIL2 Antibody (N-term)( AMM07206G). AMM07206G was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug. PIWIL2 Antibody (N-term) (Cat. AMM07206G) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the PIWIL2 antibody detected the PIWIL2 protein (arrow).
說(shuō)明書(shū)	Product Datasheet Protocol
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