全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR07979G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL15RA antibody (Center).
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分子量 |
28233 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein Nucleus membrane; Single-pass type I membrane protein. Note=Mainly found associated with the nuclear membrane Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
79-106 aa
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靶點(diǎn) |
This IL15RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of human IL15RA.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.
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總結(jié) |
This gene encodes a cytokine receptor that specificallybinds interleukin 15 (IL15) with high affinity. The receptors ofIL15 and IL2 share two subunits, IL2R beta and IL2R gamma. Thisforms the basis of many overlapping biological activities of IL15and IL2. The protein encoded by this gene is structurally relatedto IL2R alpha, an additional IL2-specific alpha subunit necessaryfor high affinity IL2 binding. Unlike IL2RA, IL15RA is capable ofbinding IL15 with high affinity independent of other subunits,which suggests distinct roles between IL15 and IL2. This receptoris reported to enhance cell proliferation and expression ofapoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternativelyspliced transcript variants of this gene have been reported.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha, IL-15R-alpha, IL-15RA, CD215, Soluble interleukin-15 receptor subunit alpha, sIL-15 receptor subunit alpha, sIL-15R-alpha, sIL-15RA, IL15RA
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圖像 |
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說明書 |
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數(shù)量 |
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